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Leptin has been found to exert various effects on epithelial cell lines, including the induction of intercellular adhesion molecule 1 (ICAM-1) expression, increased production of inflammatory mediators such as CCL11, granulocyte colony-stimulating factor (G-CSF), vascular endothelial growth factor (VEGF), and IL-6, promotion of cell migration, inhibition of apoptosis, and stimulation of epithelial cell proliferation (102)
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