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Interestingly, extracellular 13-HODE was reported to induce mitochondrial dysfunction and airway epithelial apoptosis, which was associated with its interaction with the transient receptor potential cation channel, vanilloid type 1 (TRPV1) receptor 59
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Devlin RB, McDonnell WF, Mann R, Becker S, House DE, Schreinemachers D, & Koren HS (1991) Exposure of humans to ambient levels of ozone for 6.6 hours causes cellular and biochemical changes in the lung
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