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While the threshold for stable introgression of Wolbachia in the field mosquito population is high, it can be achieved with a very small number of released females when the field mosquito population has been nearly eliminated (Pagendam et al., 2020)

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On the other hand, in carriers of a deficient methylene- tetra-hydro-folate-reductase ( MTHFR ) variant, elevated HCy due to impaired remethylation may cause increased levels of H 2 S, which has been linked to an increase in platelet activation and may contribute to the development of recurrent arterial and venous thrombosis in these patients