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System X c – System X c – , a crucial negative regulator of ferroptosis, structurally consists of the twelve-pass transmembrane transport protein cystine/glutamate transporter (SLC7A11) and the single-pass transmembrane regulator protein 4F2 cell-surface antigen heavy chain (SLC3A2), and is responsible for maintaining redox homeostasis by importing cystine to synthesize GSH [128, 129]
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