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The scaffold reported in our study is substantially more complex than any reported to date due to both (1) the anatomical complexity and increased scaffold diameter from using the whole organ with corpora and urethra rather than only one sub-unit and (2) the use of human penile specimens, with far greater scaffold size representing an additional obstacle but also an essential step to clinical translation

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Alternatively, some designs incorporate the low affinity IgG4 Fc, but require the mutation, S228P, to reduce Fab arm exchange 20