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Endothelial Dysfunction and Blood Pressure The vascular endothelium generates nitric oxide, which plays an important role in vasodilation (48,49)
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97,99,116 A 3-year interval between spirometry measurements is reasonable for patients with a low attained FEV 1 at baseline and for those with an accelerated FEV 1 decline during follow up, whereas a 5-year interval is appropriate for patients with normal FEV 1 at baseline and for those with 30-49 ml/year FEV 1 decline during follow up
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