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Effects of GSTT1 and GSTM1 polymorphisms in glutathione levels and breast cancer development in Brazilian patients | Molecular Biology Reports | Springer Nature Link

17 A patient who is a poor or intermediate metabolizer will likely achieve little or no analgesia from codeine or tramadol, as they will be minimally converted to their active metabolites, which produce significantly more analgesia

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Although we agree with the authors of previous studies who have suggested that reduced synthesis of GSH induced by liver dysfunction and increased oxidative stress might cause HCC tissue to lose its capacity to provide protection against oxidative impairment [1,11,25,31], this cannot explain why our HCC patients had lower MDA and higher GSH levels in HCC tissue when compared to its adjacent normal liver tissue