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In vivo promoter activity and transgene expression in mammalian somatic tissues evaluated by using particle bombardment
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In addition, there is also evidence that downregulation can be mediated by conformational changes (e.g., GRK-mediated phosphorylation) or internalization of receptors, which lead to the reduction in the sensitivity or activity of receptors without the loss of the total number of receptors [19,20,21]
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