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In contrast with IGF-1R-specific mAbs, which can show reduced anti-proliferative activity in heterogeneous cell populations that contain a high percentage of INSR-A-expressing cells, IGF-1/IGF-2-neutralizing mAbs should also have greater anti-tumor activity in tumors that express both IGF-1R and INSR-A, or INSR-A alone [65]
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[DOI] [PMC free article] [PubMed] [Google Scholar] 7.Khan D.A., Banerji A., Bernstein J.A., Bilgicer B., Blumenthal K., Castells M., et al
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