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At the subcellular level, the 5-HT 2A receptor is localized in both presynaptic and postsynaptic terminals, dendritic spines, and neuronal somata, as confirmed by immunomicroscopy studies 8 , 9
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Moreover, such a small molecule could serve as a tool compound to interrogate the function of the ADP-ribosyltransferase tankyrase, which is proposed to expel TRF1 from shelterin, thereby promoting telomere extension 18,19,20,21
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