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Nobiletin Nobiletin (Figure 7), a polymethoxyflavonoid isolated from citrus peel,216 has a wide range of biological effects and plays an interesting role in anticancer,217 anti-inflammatory,218 and anti-oxidation.219 Activation of the NF-ΞΊB pathway induces transcription of target genes, such as Cyclin D1, c-Myc, IL-1Ξ², IL-6, TNF-Ξ±, etc.128,129,220,221 Wei et al found that nobiletin significantly reduced the gene expression levels of IL-6, IL-1Ξ², TNF-Ξ±, matrix metalloproteinase-1 (MMP-1), and matrix metalloproteinase-3 (MMP-3)
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