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Positron emission tomography has demonstrated that sophisticated imaging techniques have a role in diagnosing complex problems like malignant peripheral nerve sheath tumours, while the prospect of targeted therapies for Nf1 complications is tantalisingly close

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Current treatments for bronchiectasis are aimed at specific treatable traits and preventable root causes, despite differences in underlying etiologies.65 The role of hypertonic saline (HS) in the management of bronchiectasis patients is crucial, as it promotes bronchial drainage, reduces mucus viscosity, enhances quality of life, and diminishes the frequency of exacerbations as well as antibiotic use.66 While the inhalation of 7% HS has been reported to be an effective strategy for mucus clearance, a significant number of patients show intolerance to this therapy