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Ferroptotic cancer cells can upregulate cyclooxygenase-2 (COX-2) expression and then elevate levels of its downstream product prostaglandin E2 (PGE2) [14], an important immune regulator capable of inhibiting chemokines CCL5 and XCL1 secreted by natural killer (NK) cells, consequently restricting cDC1 infiltration
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Our prior exploratory open-label trial supplemented GlyNAC for 24-weeks and found similar benefits as reported in this trial (66)
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