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Furthermore, bilirubin inhibits NADPH oxidase, which serves to keep ROS levels low
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An increase in reactive oxygen and nitrogen species that exceeds the ability of the antioxidant system to counteract the increase of ROS leads to an “oxidative stress state.” The antioxidant effect of ascorbate is due to its ability to donate electrons from both the second and third carbon (Padayatty et al., 2003
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