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Inhibition of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme essential for NAD+ biosynthesis, leads to altered carbohydrate metabolism in cancer cells
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Importantly, pharmacological inhibition of ferroptosis using ferrostatin‑1 or iron chelation with deferiprone has been shown to protect dopaminergic neurons and ameliorate motor deficits in toxin‑induced PD models [207], highlighting the therapeutic potential of targeting iron‑mediated toxicity
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