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Strong binding to both epidermal growth factor receptor (EGFR) and NF-κB suggests a synergistic blockade of upstream receptor-mediated and downstream transcriptional inflammatory signaling ( In silico analyses of 15 curcumin analogues show binding to multiple subdomains of cyclooxygenase-2 (COX-2), a pivotal enzyme in prostaglandin synthesis during inflammation ( in silico investigations suggest that curcumin along with quercetin, EGCG, and, resveratrol can inhibit TLR4-mediated signaling through directly interacting with TLR4 and IL-1 receptor-associated kinase 1 (IRAK1), a kinase downstream of TLR-4 ( 3.2 Gingerols and shogaols Ginger ( Zingiber officinale ), like turmeric, belongs to the Zingiberaceae family and has a long history of use as both a spice and medicinal plant

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Melatonin is helpful for regulating your body’s sleep-wake cycle and can support falling asleep, especially during travel or routine changes