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Development and validation of HILIC-MS/MS method for the analysis of glutathione metabolism in cell cultures | Analytical and Bioanalytical Chemistry | Springer Nature Link
It can cross the blood–brain barrier (BBB) to cause neurotoxicity
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Rofecoxib is a selective COX-2 inhibitor, which was evaluated in clinical trials for acute GA, and it was reported to reduce the expression of inflammatory mediators, such as IL-6, and alleviate patient pain by inhibiting COX-2-regulated AA metabolism (211)
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