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Moreover, considering that the mitochondria of every somatic cell in an organism is derived from oocyte mitochondria, and since it has been shown that the mitochondria of the female gamete produce melatonin, it is believed that this synthetic trait has been transferred to every mitochondrion in all cells (133, 134)
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the use of pro-GSH molecules (Fraternale et al., 2006) and/or glutathione precursors like N-acetyl cysteine (NAC), glutamine, cysteine (cystine) and glycine, as well as nuclear factor erythroid 2 p45–related factor 2 (Nrf2) inducers like sulforaphane can enhance glutathione production and increase nuclear Nrf2 translocation and antioxidant response element (ARE) transcription (Komaravelli and Casola, 2014
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