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The TGA’s scheduling-decision record states that AOD-9604 was initially developed as an anti-obesity drug but that the programme was discontinued in 2007 because the clinical trials did not show a meaningful weight-loss outcome across the trial population
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The oxidative branch produces both ribose-5-phosphate (R5P), which is precursor for nucleotide synthesis, and NADPH, which is not only required for biosynthesis reactions but also for antioxidant response function
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