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Mechanistically, the incubation of hemin with thiols (GSH, NAC, cysteine, mercaptoethanol, and thioglycolic acid) provokes major spectrophotometric changes in hemin despite the presence of low-affinity binders in serum [222]
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INTRODUCTION Central nervous system maintains a high metabolic rate, accounting for 20% of the overall energy consumption but only 2% of body mass.123 Such high energy consumption yields large amounts of free radicals, such as reactive oxygen species (ROS) and reactive nitrogen species (RNS)
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