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Mitochondrial fission in Huntington’s disease mouse striatum disrupts ER-mitochondria contacts leading to disturbances in Ca(2+) efflux and Reactive Oxygen Species (ROS) homeostasis
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The second trial showed no significant differences between LY-2140023 and olanzapine, risperidone, or aripiprazole groups over 6–8 weeks of treatment and further clinical investigations were ceased by the Eli Lilly company [191,195,196]
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