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Hugh S Markus: nothing to disclose Poster session I - DIAGNOSIS / ETIOLOGY 04.00 - DIAGNOSIS / ETIOLOGY - 04.07 - SMALL VESSEL DISEASE P329 - ESOC25-1687 CHOLINERGIC DISRUPTION CONTRIBUTES TO MOTORIC COGNITIVE DYSFUNCTION IN CEREBRAL SMALL VESSEL DISEASE Mengfei Cai 1,2 , Hao Li 1 , Milan Nemy 3,4 , Mina Jacob 1 , David Norris 5 , Marco Duering 6 , Yuhu Zhang 2 , Roy Kessels 5 , Lenka Vyslouzilova 4 , Stefan Teipel 7 , Daniel Ferreira Padilla 3,8 , Frank-Erik De Leeuw 1 , Anil Tuladhar 1 1 Department of Neurology, RadboudUMC, Nijmegen, Netherlands, 2 Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Guangzhou, Netherlands, 3 Karolinska Institute, Stockholm, Sweden, 4 Czech Technical University in Prague, Prague, Czech Republic, 5 Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands, 6 University of Basel, Basel, Switzerland, 7 Rostock University Medical Center, Rostock, Germany, 8 Universidad Fernando Pessoa Canarias, Las Palmas, Spain Background and Aims: Cerebral small vessel disease (SVD) is a key vascular contributor to both cognitive and motor dysfunction, consequently leading to an increased risk of dementia, parkinsonism, and loss of functional independence