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A specific miRNA may aid the progression of some cancers while acting as an oncogenic repressor in others.[49] 1.4 Nucleosome rearrangement Studies have found that changes in the arrangement of nucleosomes are related to gene transcription and malignancy.[50] Several reports have focused on how nucleosomes are arranged around genes, particularly in 5’ transcriptional regions.[51] As an example, normal cells lack nucleosomes in the promoter regions of the hypomethylated tumor suppressor MLH1
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