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Once a patient is on a maintenance dose, their B12 levels are generally stable, and a single dayโs difference is unlikely to have a clinical impact
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MRGPRX2 is activated by a wide variety of endogenous and exogenous ligands (e.g., substance P, defensins, LL-37) and triggers mast cell degranulation, leading to the release of histamine, cytokines, and other mediators that fuel inflammation and itch ๐ฅ
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