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Regarding mitophagy during HFD, it has been found that in healthy, non-obese, sedentary males and 10 endurance-trained male runners, the protein content of total PTEN-induced kinase 1 (PINK1) in skeletal muscle was found to be similar between groups before and after a high-fat meal, indicating that mitophagy is not required for metabolic flexibility in the healthy population [163]

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The 5xFAD transgenic mouse line has been genetically engineered to model features of AD through the expression of human amyloid precursor protein (APP) and presenilin-1 transgenes, which are associated with early-onset AD (Brody et al., 2017)