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3 Contribution of MMPs in hypertension-induced vascular remodeling and dysfunction The activation of the 72 kDa MMP-2 in vasculature causes hypertrophic maladaptive remodeling and dysfunction in many experimental models of hypertension, such as two-kidney, one-clip (2K-1C) rats (Castro et al., 2008), deoxycorticosterone acetate (DOCA)-salt rats (Watts et al., 2007), and AngII infusion in rodent by osmotic mini-pumps (Ramos et al., 2025)
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[DOI] [PubMed] [Google Scholar] 25.Wang G.M., Raghavachari N., Lou M.F
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