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Clozapine is a full agonist at the muscarinic M4 receptor (EC 50 =11 nM) expressed in CHO cells [4]
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Hypoxia stress encourages the binding of YAP1 and HIF-1Ξ± in the nucleus, directly activates pyruvate kinase M2 (PKM2) transcription, and finally accelerates the glycolysis phenotype in HCC cells (124)
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