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Who should avoid this combination Certain populations should exercise extra caution or avoid the semaglutide/L-carnitine combination entirely: Individuals with a history of seizure disorders (high-dose L-carnitine may lower seizure threshold in susceptible individuals) People with hypothyroidism on thyroid replacement therapy (L-carnitine may affect thyroid hormone levels) Individuals with kidney disease (impaired carnitine clearance may lead to accumulation) Pregnant or breastfeeding individuals (semaglutide is contraindicated) Anyone with a known allergy to either component L-carnitine compared to other semaglutide additives L-carnitine is not the only substance that compounding pharmacies add to semaglutide
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