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Full article: The central role of glutathione in the pathophysiology of human diseases

Additionally, modification on Cys170 is believed to influence activity as well (Orton and Liebler, 2007), which is also explained by its importance in dimerization (Chang et al., 1997

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In contrast to our finding, another study has reported decreased testicular weight and density, reduced diameter and height of germ epithelium in seminiferous tubules, and decreased Leydig cell count in STZ-induced diabetic rats.46 This is a pertinent finding as Leydig cells function to synthesize and release testosterone that acts on peritubular cells and Sertoli cells within the testis to stimulate spermatogenesis.47,48 The disparities in results may be attributable to several factors