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Dr. Desalegn Mengesha Degefaw has announced his resignation after serving UoG for the past thirteen years. His destination is Ohio State University's Global One Health Initiative (Regional Director for East Africa)! I

By using senolytics to remove senescent endothelial and smooth muscle cells, combined with senomorphics like rapamycin to modulate the SASP, this dual approach could reduce arterial stiffness, improve vascular function, and lower the risk of heart attacks and stroke.211,212 Neurodegenerative Diseases: Conditions like Alzheimer’s disease, Parkinson’s disease, and other forms of dementia are characterized by neuroinflammation and the accumulation of senescent cells in the brain.26 Combination therapies targeting both senescent cells and the neuroinflammatory SASP could slow disease progression, improve cognitive function, and promote neuronal repair.213 Senolytics like dasatinib and quercetin, combined with senomorphic agents such as NMN, could help rejuvenate neuronal tissue and prevent cognitive decline.214 Osteoporosis and Sarcopenia: Aging is associated with a decline in bone density and muscle mass, partly driven by the accumulation of senescent cells in bone and muscle tissue

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doi: 10.1016/j.bbapap.2005.08.017