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Published laboratory work examines GHK-Cu primarily in skin and tissue-remodelling models — extracellular matrix turnover, collagen and glycosaminoglycan expression in fibroblast culture, and related gene-expression endpoints

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Formation of GSH conjugates can be detected by mass spectrometry, which, in turn, provides insight into the reactive metabolite structure.96,97 With the possible exception of acyl glucuronides and cyclic iminium ions, most reactive metabolites are generally short-lived and are not usually detectable in circulation