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This gene was also down-regulated when we compared the acne patients to the healthy individuals in our cross-sectional study (fold change=0.76, P =0.075, n =4 acne patients and 5 healthy individuals, Student’s t-test) (fig
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The lack of human data for SLU-PP-332 is particularly critical, as small-molecule agonists can have off-target effects not apparent in murine models
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