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The effects of beta-blockers on renal function may depend on several factors, such as the degree of cardioselectivity (i.e., the selectivity for beta-1 receptors over beta-2 receptors), the intrinsic sympathomimetic activity (i.e., the partial agonist activity at beta receptors), the lipid solubility (i.e., the ability to cross the blood–brain barrier), and the route of administration (i.e., oral or intravenous) of the drug [97]