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Major differences from 2-Cys Prdxs include the use of glutathione (GSH) instead of thioredoxin as the physiological reductant, heterodimerization with πGSH S-transferase as part of the catalytic cycle, and the ability either to reduce the oxidized sn -2 fatty acyl group of phospholipids (peroxidase activity) or to hydrolyze the sn -2 ester (alkyl) bond of phospholipids (phospholipase A 2 [PLA 2 ] activity)
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