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Mechanisms behind its fat-loss potential: Enhanced GH-induced lipolysis Preservation of lean tissue in a calorie deficit Increased metabolic rate via improved thyroid conversion and mitochondrial efficiency Improved insulin sensitivity in controlled dosages and healthy individuals “Growth hormone secretagogues, including MK-677, have been shown to reduce visceral adiposity while preserving lean mass in hypocaloric states.” — Smith et al., Clinical Endocrinology 4

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Free Radic Biol Med 169: 382–396, 2021