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The negative coefficient values for X 1 X 2 , X 1 X 4 , X 2 X 3 , X 2 X 4 , X 3 X 4 interaction effects between variables and for the quadratic effects of the process variables (X 1 2 , X 2 2 , X 3 2 and X 4 2 ) indicate that these factors exert a negative effect on Sv-CollNPs biofabrication (Table 3)

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