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However, PDE5Is is a well-researched mechanism that has been widely used for treatment of ED, and has been supported by previous studies for treatment of corporal fibrosis and PD (Ferrini et al., 2006a
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The mitochondria are the primary intracellular site of oxygen consumption and, despite the presence of a wide array of antioxidants and detoxifying enzymes, are the major source of reactive oxygen species (ROS), most of them originating from the mitochondrial respiratory chain
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