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In a 1992 study in rats, the major finding was that intraperitoneal DSIP injection increased the concentration of substance P — a neurotransmitter positively correlated with the regulation of anxiety and mood15 — in the hypothalamus, suggesting to the researchers that the peptide “sharply decreases the classical manifestations of stress.”16 Earlier studies in humans, namely a series of five trials published in 1983, came to similar conclusions, with “better relaxation” and “apparently improved tolerance against psychic stress” reported by the subjects.17 It’s possible that the improved stress and anxiety markers were consequent to DSIP-associated sleep enhancements.18 Substance use recovery A study from 1984 published in European Neurology describes DSIP’s potential use as a treatment for alcohol and opiate use disorders