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Despite multimodal interventions (surgery, radiotherapy, chemotherapy), median overall survival is generally reported as 4–6 months, with only 10–20% of patients surviving past one year [124]
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H 2 O 2 has a longer half-life and can cross membranes (Sies, 2014), which confers properties to H 2 O 2 as a mitochondrial signal (Raimundo, 2014)
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