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The product of these methylation reactions is S-adenosylhomocysteine (SAH), which can be hydrolysed into homocysteine (Hcy) by S-adenosylhomocysteine hydrolase (AHCY), then resynthesized into Met by MS using 5-mTHF as a methyl donor and B12 as an essential cofactor [8,17,32]
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