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1,4 Adverse events ≥ 5% in SUSTAIN 4 9 AEs occurring in ≥ 5% of participants treated with Ozempic ® injection in SUSTAIN 4 SUSTAIN 4 was not designed to evaluate relative safety between Ozempic ® injection and Lantus ® In placebo-controlled trials, the most common adverse reactions reported in ≥5% of patients treated with Ozempic ® injection are nausea, vomiting, diarrhea, abdominal pain, and constipation 1 Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice 1 Comparator AE rates are not an adequate basis for comparison of safety between products 1 Incidence of severe hypoglycemia was ≤1.5% across all placebo-controlled trials 1 Incidence of severe hypoglycemia or blood glucose-confirmed hypoglycemia (% of patients) was 4% with Ozempic ® injection 0.5 mg, 6% with Ozempic ® injection 1 mg, and 11% with Lantus ®9,a Adverse events ≥5% in SUSTAIN FORTE 4 AEs occurring in ≥5% of patients receiving Ozempic ® injection 1 mg and 2 mg in SUSTAIN FORTE In placebo-controlled trials, the most common adverse reactions reported in ≥5% of patients treated with Ozempic ® injection are nausea, vomiting, diarrhea, abdominal pain, and constipation 1 No new safety signals were identified

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Научный контекст: SS-31 при 8 нед значимо повысил выносливость на беговой дорожке у старых животных — восстановил редокс-гомеостаз скелетной мускулатуры и митохондриальную функцию без увеличения митохондриальной массы