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34 The dataset combines four other data sets, 36,53,71,72 which are categorized as BBB-permeable (LogBB ≥ −1, with LogBB defined as the logarithmic ratio between the concentration of a compound in the brain and blood) and BBB-nonpermeable (LogBB 5 or bioactivity 10,000 nM, or alternatively their comment section in ChEMBL containing the keywords “inactive” or “not active” were annotated as “inactive”
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