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“Beyond Barriers is confident the results will be more robust when delivered intranasally.” Using a repurposed drug lets the company pursue the 505(b)(2) FDA approval pathway, which Kole says, “has a three-fold better chance of success of approval than the traditional 505(b)(1) route and is less expensive and time-intensive.” Administration doses and schedules are to be determined, but early research suggests the administration window may be as long as 72 hours after injury

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In this study, we investigated the role of reduced GSH in modulating cuproptosis in AKI using a sepsis-induced mouse model