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However, in a double-blind, placebo-controlled phase II trial of TSO in adults with active Crohn’s disease (n = 252), ingestion of 250-7500 TSO fortnightly over 12 weeks was observed to be safe without any adverse effects, but the treatment did not have an advantage over the placebo in inducing clinical remission and other immunological responses (Scholmerich et al., 2017)
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