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In addition, chemicals (Cys, GSH, and MIX) were treated in the presence or absence of ethanol (700 mM) for 24 h to confirm the protective effect of chemicals against ethanol-induced cytotoxicity
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Furthermore, CPI-613 suppresses the proliferation of multiple myeloma cells by inducing mitochondrial metabolic dysfunction through the targeting of pyruvate dehydrogenase E1 subunit alpha 1 (PDHA1) and oxoglutarate dehydrogenase (OGDH), and it produces significant anti-tumor effects when combined with bortezomib at a lower dose [88]
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