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Comparing the glutathione-scaffold site among a variety of other members of the thioredoxin superfamily also provides an explanation for their disulfide substrate preferences, for example, why glutaredoxins prefer GSSR in contrast to thioredoxins lacking most of the relevant residues (Fig

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89 Elevated EV concentrations in the peripheral blood of GBM patients, independent of specific molecular alterations (EGFR amplification, PTEN deletion, MGMT expression, and IDH mutations), 90 suggest their broad applicability in GBM detection, prognosis, and relapse prediction